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科学研究

吴志生 研究员 硕士生导师

 

   吴志生,中共党员,博士,研究员。中华中医药学会中青年创新领军人才,中国仪器仪表学会青年科技人才,北京科技新星,北京中医药大学杰出青 年人才。教育部中药制药与新药开发关键技术工程中心、国家中医药管理局中药信息工程重点研究室、北京市中药生产过程控制与质量评价重点实验室等省部级平台方向负责人;中国仪器仪表学会中药分析及标准化检测技术培训中心(筹)主任;中国科协“创新驱动助力工程”项目组专家及中药领域召集人,中药智能制造杰出青年科学家论坛(主席);国家中医药管理局中药分析学和中医药信息学重点学科核心成员。国家自然科学基金委、教育部、科技部及北京市项目评审专家。

   致力于中药质量设计、中药先进制药控制技术研究,聚焦中药制药过程智能检测,中药质量信息感知和名医名方质量源于设计,开展了系统化研究,研制了中药功能指标的在线检测技术、多维数据的信息融合技术和光机电一体化技术等一批关键技术,解决了中药生产过程质量控制中的共性关键技术问题。成果转化为企业创造良好的经济和社会效益。成果得到教育部科技发展中心等官方媒体报道。

   主持国家自然科学青年基金、面上项目、国家博士点基金、国家重大新药创制子课题等课题10余项,组织实施十一五、十二五重大新药创制等课题20余项。发表论文97篇,第一或通讯作者在Journal of Controlled Release(7.78), Scientific Reports(IF 5.57),Bioresource Tech(IF 5.03)等SCI 50篇。专利2项,规划教材1项、蓝皮书1项和著作2项。合作指导访问学者2名,博士研究生2名,硕士研究生10名,8人获国家奖学金。中国仪器仪表学会药物质量分析与过程控制分会秘书长,世界中医药联合会中药系统科学与工程常务理事,中华中医药学会中药分析委员会委员,世界中医药联合会中药学专业委员会委员,中国中药协会中药产品开发与培育专业委员会委员,中国仪器仪表学会近红外专业委员会理事、中国民族医药学会信息与大数据分会理事等。福建中医药大学、哈尔滨商业大学兼职硕士导师。中华中医药杂志、世界中医药英文版、计算机与应用化学杂志青年编委,20余份SCI杂志审稿人。获北京市科学技术奖一等奖,中华中医药学会十大论文奖,国家卫计委第十二届全国医药卫生青年科技论坛三等奖,北京中医药大学科学技术进步一等奖,第三届全国中医药博士生优秀论文奖,北京中医药大学优秀博士学位论文等。

 

主要研究兴趣

1. 中药先进制药、在线检测与过程控制;
2. 名医名方质量源于设计;
3. 中药人工智能与性味信息感知;

 

教育经历

1. 2009/9–2012/6,北京中医药大学,中药学,博士,导师:乔延江

2. 2006/10–2008/12,北京大学(联合培养),硕士,导师:徐筱杰

3. 2006/9–2009/7,福建中医药大学,中药学,硕士,导师:胡娟

4. 2002/9–2006/7,福建中医药大学,中药学,学士,导师:郭素华

 

工作经历

1. 2016/12-至今,北京中医药大学,中药学院,研究员

1. 2014/10-2016/12,北京中医药大学,中药学院,副研究员

2. 2012/9-2016/7,北京中医药大学,中药学院,班主任

3. 2012/7-2014/10,北京中医药大学,中药学院,讲师

 

称号与奖项

2017年获中华中医药学会中青年创新人才奖

2017年获北京市科学技术一等奖(7)

2016年北京中医药大学就业先进个人

2016年获中国仪器仪表学会青年科技人才奖

2016年获中华中医药学会十大论文奖

2016年入选北京科技新星人才计划

2015年入选北京中医药大学杰出青年人才计划

2015年获第十二届全国医药卫生青年科技三等奖

2013年北京中医药大学中药学院中保康优秀论文奖

2012年获北京中医药大学中药学院SCI标兵

2012年获北京中医药大学优秀博士学位论文

2012年获北京中医药大学优秀毕业生

2012年获北京市优秀毕业生

2010年获第三届全国中医药博士生优秀论文奖

2010年获北京中医药大学科学技术一等奖

2009年获福建省优秀毕业生

2008年获福建省陈可冀院士优秀论文三等奖

 

国际国内学术组织兼职

2013-05-28,ICBEB2013, international Committee

2014-09-23,中华中医药学会中药分析分会,委员

2014-09-23,中国仪器仪表学会近红外专业委员会,理事

2014-10-24,世界中医药联合会中药学专业委员会,理事

2014-12-10,中国中药协会中药产品开发与培育专业委员会,委员

2015-01-01,受聘于福建中医药大学兼职研究生导师

2015-07-02,受聘于哈尔滨商业大学兼职研究生导师

2016-05-26,中华中医药杂志,青年编委

2016-08-20,中华中医药学会中医体质分会,青年委员

2016-07-20,世界中医药联合会中药学委员会,理事

2017-07-20,世界中医药联合会中药系统科学与工程分会,常务理事

2017-11-24,中国仪器仪表学会药物质量分析与过程控制分会,秘书长

2017-11-24,中国民族医药学会信息与大数据分会,理事

2017-12-17,世界中医药英文版杂志,青年编委

2017-12-30,计算机与应用化学杂志,青年编委

受聘于Scientific Reports,J. Pharm. Biomed,Spectrochimica Acta A,Planta Medica,Sensors,分析化学等20余份SCI杂志审稿人。

 

承担科研项目

1. 国家自然科学基金项目:基于系统建模的中药制药过程实时监测可靠性研究(81773914)

2. 国家自然科学基金项目:多源信息融合的中药近红外模型适用性评价方法研究(81303218)

3. 高等学校博士学科点专项科研基金:基于构谱关联的中药近红外检测规律研究(20130013120006) 

4. 国家中医药行业科研专项:NIR模型群的金银花与山银花质量快速可靠性评价研究(201407003) 

5. 北京市科技新星计划: 中药过程分析(xx2016050) 

6. 北京中医药大学杰出青年基金:中药质量实时分析(2015-JYB-XYQ-003)

7. 北京中医药大学优秀青年教师专项课题:中药制药过程分析中NIR多变量模型评价新方法研究 

8.北京中医药大学校级课题:黄酮类成分的近红外MDL与MQL规律研究(2013-X-043)  0

9.北京中医药大学自主课题:基于PAT的乳块消片过程质量评价方法学研究(2009JYB22-X3039)

10. 陈可冀院士中西医发展基金:中药注射剂分子聚集体的研究及安全性探讨(ckj2008053) 

11.北京宝洁技术有限公司:近红外光谱快速测定XXX含量的方法开发(30500643) 

12.北京宝洁技术有限公司:微机电近红外光谱快速测定XXX含量的方法开发(30500644) 

 

教材与著作

1. 褚小立(主编), 许育鹏, 吴志生, 陈瀑, 李敬岩, 过程分析技术——针对化学和制药工业的光谱方法和实施策略, 机械工业出版社,ISBN:9787111474647,2014-8,编委

2. 李飞雁(主编),宋永刚,赵珍东,姬水英,王玉霞,任丽萍,吴志生,邱佳,何舒澜,赵宝林,姚巧林,景晓奇,曾彬,廖广辉,中药学,中国中医药出版社,2015, 编委

3. 褚小立(主编), 吴志生等, 近红外光谱分析技术实用手册, 机械工业出版社, 2015-10,编委

4. 宫晓冬(主编), 吴志生等,2017中国互联网健康医疗发展报告(蓝皮书),社会科学文献出版社,2017-10,编委

 

论文与专利

专利

1.史新元,乔延江,吴志生,隋丞琳, 一种取样系统,ZL201020568372.1,中国

2.史新元,乔延江,吴志生,隋丞琳, 一种取样系统,ZL 201210348207.9,中国

3. 马群,解素花,乔延江,顾海鸥,杜菁,吴炜,吴志生,徐冰,一种中药组合物制剂的指纹图谱检测方法,ZL201310394990.7,中国

 

第一或通讯作者SCI论文

49. Y, F.-L.; Zhao, N.; Wu, Z.-S. *; Huang, M.; Wang, D.; Zhang, Y.-B.; Hu, X.; Chen, X.-L.; Huang, L.-Q.; Pang, Y.-X*. NIR Rapid Assessments of Blumea balsamifera (Ai-na-xiang) in China. Molecules, 2017, 22, 1730.

48. M Xiao-Su, CUI Qing-Yu, W Zhao-Yi, Yanjiang Qiao*, Zhisheng Wu*. Advance in quality assessment of Chinese materia medica using microscopic and morphological methods, Chinese Journal of Natural Medicines, 2017, 15, 653-663.

47. Xiaona Liu; Shifeng Wang; Zhisheng Wu*; Zhaoyi Wang; Yanjiang Qiao*, Scientific fusion of liver-based therapy of traditional Chinese medicine theory and modern deoxyschizandrin nano-delivery system on the hepatoprotective activity, ournal of Controlled Release. 2017,259,149–150.

46. C Du, S Dai, Y Qiao*, Z Wu*. Error propagation of partial least squares for parameters optimization in NIR modeling,Spectrochimica Acta Part A, 2018,192, 244-250.

45. WU Zhi-sheng, LIU Xiao-na, TAN Peng, PEI Yan-ling, DAI Xing-xing, QIAO Yan-jiang*. Research on Steaming Procedure of Aconite Root with FTIR and Two-Dimensional IR Correlation Spectroscopy. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2017, 37(06): 1745-1748.

44. Jing Li, Yanjiang Qiao, Zhisheng Wu*, Nanosystem trends in drug delivery using quality-by-design concept, Journal of Controlled Release, 2017, 256, 9-18.

43. Manfei Xu, Shengyun Dai, Zhisheng Wu*, Xinyuan Shi, Yanjiang Qiao*. Rapid analysis of dyed safflowers by color objectification and pattern recognition methods, Journal of Traditional Chinese Medical Sciences, 2016, 3, 4, 234–241

42. Xiaosu Miao, Qingyu Cui, Honghui Wu, Yanjiang Qiao, Yanfei Zheng, Zhisheng Wu*. New sensor technologies in quality evaluation of Chinese materia medica: 2010–2015, Acta Pharmaceutica Sinica B, 2017,7,137-145.

41. Manfei Xu, Chenzhao Du, Na Zhang, Xinyuan Shi, Zhisheng Wu*, Yanjiang Qiao*. Color spaces of safflower (Carthamus tinctorius L.) for quality assessment, Journal of Traditional Chinese Medical Sciences, 2016, 3, 3, 168-175.

40. Xiaoying Li1, Zhisheng Wu1, Xin Feng, Shanshan Liu, Xiaojie Yu, Qun Ma, Yanjiang Qiao. Quality-by-Design: Multivariate model for multicomponent quantification in refining process of honey, Phcog Mag 2017;13:193-8. (1Co-first authors).

39. Manfei Xu, Luwei Zhou, Qiao Zhang, Zhisheng Wu*, Xinyuan Shi, Yanjiang Qiao, Near-infrared chemical imaging for quantitative analysis of chlorpheniramine maleate and distribution homogeneity assessment in pharmaceutical formulations, J. Innov. Opt. Health Sci, 2016, 9(4), 1-9.

38. Na Zhao, Zhisheng Wu*, Yaqian Cheng, Xinyuan Shi, Yanjiang Qiao*. MDL and RMSEP assessment of spectral pretreatments by adding different noises in calibration/validation datasets, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 163 (2016) 20–27.

37. Zhisheng Wu, Guang Wan, Cuicui Su, Meiwan Chen, Xinyuan Shi, Dehai Liang*, Yanjiang Qiao*, Nano-analysis of triptolide liposomes for potential therapy of prostate cancer, Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 12(2), 528-528.

36. Zheng Zhou, Yang Li, Xinyuan Shi, Zhisheng Wu*, Yanjiang Qiao*. Comparison of ensemble strategies in on-line NIR for monitoring the extraction process of Pericarpium Citri Reticulatae based on different variable selections. Planta Medica, 2016,82: 1-2:154-162.

35. Xiaoning Pan, Feiyan Li, Zhisheng Wu*, Qiao Zhang, Zhaozhou Lin, Xinyuan Shi and Yanjiang Qiao. Near infrared spectroscopy model development and variable importance in projection assignment of particle size and lobetyolin content of Codonopsis radix. J Near Infrared Spec, 2015, 5, 327–335.

34. Na Zhao, Zhisheng Wu*, Qiao Zhang, Xinyuan Shi, Qun Ma, Yanjiang Qiao*, Optimization of Parameter Selection for Partial Least Squares Model Development, Scientific Reports, 5, 11647, doi: 10.1038/srep11647 (2015).

33. Liu Xiaona, Huang Jianmei, Wu Zhisheng*, Zhang Qiao, Shi Xinyuan, Zhao Na, Jia Shuaiyun, Qiao Yanjiang*, Microanalysis of multi-element in Juncus effusus L. by LIBS Technique, plasma science and technology, 2015, 17, 904-906.

32. Xiaoning Pan, Yang Li, Zhisheng Wu*, Qiao Zhang, Zhou Zheng, Xinyuan Shi, Yanjiang Qiao*, A Online NIR Sensor for the Pilot-Scale Extraction Process in Fructus Aurantii Coupled with Single and Ensemble Methods, Sensors, 2015, 15, 8749-8763.

31. Luwei Zhou, Manfei Xu, Zhisheng Wu*, Xinyuan Shi, Yanjiang Qiao*, PAT: From Western solid dosage forms to Chinese materia medica preparations using NIR-CI, Drug Testing and Analysis, 2016, 8(1):71-85.

30. Xiaona Liu, Qun Ma, Shanshan Liu, Xinyuan Shi, Zhisheng Wu*, Yanjiang Qiao*. Monitoring As and Hg variation in An-Gong-Niu-Huang Wan (AGNH) intermediates in a pilot scale blending process using laser-induced breakdown spectroscopy. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2015,151, 547-552.

29. Xiaona Liu, Qiao Zhang, Zhisheng Wu*, Xinyuan Shi, Na Zhao, Yanjiang Qiao*. Rapid Elemental Analysis and Provenance Study of Blumea balsamifera DC Using Laser-Induced Breakdown Spectroscopy. Sensors, 2014, 15(1), 642-655.

28. Yanling Pei, Zhisheng Wu*, Xinyuan Shi, Xiaoning Pan, Yanfang Peng, Yanjiang Qiao*. NIR assignment of Magnolol by 2D-COS technology and model application in Huoxiangzhengqi Oral Liquid, Spectroscopy and Spectral Analysis, 2015, Doi 10.3964/j.issn.1000-0593

27. Yanling Pei, Zhisheng Wu*, Xinyuan Shi, Xiaoning Pan, Yanfang Peng, Yanjiang Qiao*. NIR assignment of Isopsoralen by 2D-COS technology and model application in Yunkang Oral Liquid, J. Innov. Opt. Health Sci, 2015, 8(6), 1-8.

26. Yang Li, Mingye Guo, Xinyuan Shi, Zhisheng Wu*, Jianyu Li, Bing Xu, Qun Ma and Yanjiang Qiao*, On-line NIR analysis for multi-ingredients and multi-phases extraction in Radix Glycyrrhizae coupled with MWPLS and SiPLS models, Chinese medicine, 2015, doi.10.1186/s13020-015-0069-2.

25. Zhisheng Wu, Xinyuan Shi*, Guang Wan, Manfei Xu, Yanjiang Qiao*, MEMS-NIR validation of different sampling modes and sample sets coupled with multiple models, Planta Medica, 2015, 81, 167-174.

24. Zhisheng Wu, Luwei Zhou, Bing Xu, Shengyun Dai, Xinyuan Shi, Yanjiang Qiao*, Evaluation of NIR spectromicroscopy for the analysis of glycyrrizhic acid in licorice, Chinese Journal of Natural Medicines, 2015, doi: 10.3724/SP.J.1009.2015.00000.

23. Yifei Wang, Zhisheng Wu*, Zhaoyi Wang, Manfei Xu, Xinyuan Shi, Yanjiang Qiao*. Rapid analysis of spatial distribution of PVPP and hardness of Yinhuang dispersible tablets by NIR-CI, J. Innov. Opt. Health Sci. 2015, 8(5). 1-7.

22. Yang Li, Zhisheng Wu*, Qun Ma, Xinyuan Shi, Yanjiang Qiao*, Near-infrared for on-line determination of quality parameter of Sophora japonica L. (formula particles): From lab investigation to pilot-scale extraction process, Pharmacognosy Magazine, 11, 2015, 8-13. 

21. Zhisheng Wu*, Guoqing Ouyang, Xinyuan Shi, Qun Ma, Guang Wan, Yanjiang Qiao*. Absorption and quantitative characteristics of C-H bond and O-H bond of NIR, Optics and Spectroscopy, 2014, 117, 703-709.

20. Zhisheng Wu, Min Du, Xinyuan Shi, Bing Xu, Yanjiang Qiao*.Robust PLS prediction model for Saikosaponin A in Bupleurum chinense DC. coupled with granularity-hybrid calibration set, Journal of Analytical Methods in Chemistry, 2014, 1-7. http://dx.doi.org/10.1155/2014/583841.

19. Zhisheng Wu*, Xinyuan Shi, Zhao N, Y Pei, Manfei Xu, Luwei Zhou, Yang Li, Yanjiang Qiao*. Estimation of multivariate detection limits of four quality parameters in licorice using MEMS–NIR spectrometry coupled with two sampling accessories[J]. Journal of Innovative Optical Health Sciences 2014, 8(4), 1-10.

18. Luwei Zhou, Zhisheng Wu*, Xinyuan Shi, Manfei Xu, Bing Xu, Yanjiang Qiao*, Rapid discrimination of chlorpheniramine maleate and assessment of its surface content uniformity in a pharmaceutical formulation by NIR-CI coupled with statistical measurement, Spectroscopy, 2014, 1-9.

17. Luwei Zhou, Zhisheng Wu*, Xinyuan Shi, Manfei Xu, Qiao Zhang, Yanjiang Qiao*. ZHANG Q. The Research on NIR-CI Parameters Optimization of Chlorpheniramine Maleate Tablets Based on Binary Image and Statistical Measurement [J]. Spectroscopy and Spectral Analysis, 2014, 34(10), 2821-2826.

16.Yang Li, Zhisheng Wu*, Xiaoning Pan, Xinyuan Shi, Mingye Guo, Bing Xu, QIAO Yan-jiang*. Applications and Prospects of On-Line Near Infrared Spectroscopy Technology in Manufacturing of Chinese Materia Medica [J]. Spectroscopy and Spectral Analysis, 2014, 10, 2632-2638.

15. Yanling Pei, Zhisheng Wu*, Xinyuan Shi, Luwei Zhou, Yanjiang Qiao*. Rapid Assessment of Critical Quality Attributes of Chinese Materia Medica (Ⅱ): Strategy of NIR Assignment[J]. Spectroscopy and Spectral Analysis 2014, 34, 2391-2396.

14. Zhao Chen, Zhisheng Wu*, XinYuan Shi, Bing Xu, Na Zhao, Yanjiang Qiao*. A Study on Model Performance for Ethanol Precipitation Process of Lonicera japonica by NIR Based on Bagging-PLS and Boosting-PLS algorithm. Chinese Journal of Analytical Chemistry, 2014,11,1679-1686.

13. Zhisheng Wu, Yanfang Peng, Wei Chen, Bing Xu, Qun Ma, Xinyuan Shi, Yanjiang Qiao*. NIR spectroscopy as a process analytical technology (PAT) tool for monitoring and understanding of a hydrolysis process. Bioresource Technology,137, 2013, 394-399.

12. Zhisheng Wu, Qun Ma, Zhaozhou Lin, Yanfang Peng, Lu Ai, Xinyuan Shi, Yanjiang Qiao*. A Novel Model Selection Strategy Using Total Error Concept. Talanta, 2013, 30,248-254.

11. Zhisheng Wu, Chenglin Sui, Bing Xu, Lu Ai, Qun Ma, Xinyuan Shi, Yanjiang Qiao*. Multivariate detection limits of on-line NIR model for extraction process of chlorogenic acid from Lonicera japonica. Journal of Pharmaceutical and Biomedical Analysis, 2013, 77,16-20.

10. Yanfang Peng, Xinyuan Shi, Luwei Zhou, Yanling Pei, Yang Li, Zhisheng Wu*, Qiaoyan Jiang*. Multivariate detection limit of baicalin in Qingkailing injection based on four NIR technology type. Spectroscopy and Spectral Analysis. 2013, 09.2363-2368.

9. Zhisheng Wu, Min Du, Bing Xu, Zhaozhou Lin, Xinyuan Shi, Yanjiang Qiao*. Absorption characteristics and quantitative contribution of overtones and combination of NIR: Method development and validation. Journal of Molecular Structure, 1019 (2012) 97–102.

8. Zhisheng Wu, Ou Tao, Xinxing Dai, Xinyuan Shi, Yanjiang Qiao*. Monitoring blending process of Yinhuang powder by near infrared chemical imaging. Vibrational Spectroscopy, 63(2012) 373-379. 

7. Zhisheng Wu, Min Du, Chenglin Sui, Xinyuan Shi, Yanjiang Qiao*. Development and validation of PLS model using low-concentration calibration range: rapid analysis of solution from Lonicera japonica in ethanol precipitation process. Analytical Methods. 2012. 4. 1084-1088.

6. Zhisheng Wu, Min Du, Chenglin Sui, Xinyuan Shi, Yanjiang Qiao*.Validation of a NIR quantification method for the determination of chlorogenic acid in Lonicera japonica solution in ethanol precipitation process. Journal of Pharmaceutical and Biomedical Analysis. 2012, 62, 1-6.

5. Zhisheng Wu, Ou Tao, Wei Cheng, Lu Yu, Xinyuan Shi, Yanjiang Qiao*. Visualizing Excipient Composition and Homogeneity of Compound Liquorice Tablets by Near-Infrared Chemical Imaging. Spectrochimica Acta Part A. 2012, 86, 631-636

4. Zhisheng Wu, Ou Tao, Wei Cheng, Lu Yun, Xinyuan Shi, Yanjiang Qiao*. Research on spatial distribution and composition uniformity of Rukuaixiao tablets intermediate by spectral imaging. Chinese Journal of Analytical Chemistry, 2011, 5, 628-634. 

3. Zhenfeng Hong1, Wang Chen1, Jinyan Zhao1, Zhisheng Wu1, JianHeng Zhou, Tianjiao Li and Juan Hu*, Hepatoprotective effects of Rubus aleaefolius Poir. and identification of its active constituents. Journal of Ethnopharmacology. 2010, 129, 267–272. (1Co-first authors).

2. Juan Hu1 and Zhisheng Wu1, Jingjing Yan, Wensheng Pang, Dehai Liang*, Xiaojie Xu*. A promising approach for understanding the mechanism of Traditional Chinese Medicine by aggregation morphology. Journal of Ethnopharmacology. 2009, 123, 267–274. (1Co-first authors).

1. Zhisheng Wu, Jing Zhang, Wang Chen, Juan Hu*. Studies on the Aggregation and Interaction of Daidzin with Bovine Serum Albumin by Fluorescence Spectrum and Laser Light Scattering. Acta Chim. Sinica. 2009, 67(14), 1609-1614.

 

 

核心论文

[1]吴志生,徐冰,王耘,史新元,乔延江*. 朝向过程系统工程的中药制药工业发展战略[J]. 中华中医药杂志,2016,09:3417-3419.

[2]周正,吴志生*,史新元,王佳茜,乔延江*. Bagging-PLS的黄柏中试提取过程在线近红外质量监测研究[J]. 世界中医药,2015,12:1939-1942.

[3]徐曼菲,吴志生*,刘晓娜,史新元,乔延江*. 从辨色论质谈中药质量评价方法[J]. 中国中药杂志,2016,02:177-181.

[4]詹雪艳,赵娜,林兆洲,吴志生,袁瑞娟,乔延江*. 校正集选择方法对于积雪草总苷中积雪草苷NIR定量模型的影响[J]. 光谱学与光谱分析,2014,12:3267-3272.

[5]李洋,吴志生*,史新元,潘晓宁,张乔,乔延江*. 中试规模和不同提取时段的黄芩配方颗粒质量参数在线NIR监测研究[J]. 中国中药杂志,2014,19:3753-3756.

[6]裴艳玲,吴志生*,史新元,潘晓宁,刘晓娜,乔延江*. 基于“辛甘化阳,酸甘化阴”思想的桂枝-白芍药对配比的液质联用分析[J]. 世界科学技术-中医药现代化,2014,10:2180-2184.

[7]周璐薇,吴志生*,史新元,裴艳玲,乔延江*. 中药关键质量属性快速评价:近红外化学成像可视化技术[J]. 世界科学技术-中医药现代化,2014,12:2568-2574.

[8]刘晓娜,史新元,贾帅芸,赵娜,吴志生*,乔延江*. 基于LIBS技术的藏药“佐太”快速元素分析研究[J]. 世界科学技术-中医药现代化,2014,12:2582-2585.

[9]吴志生,杜敏,潘晓宁,史新元*,乔延江*. 粒径对多类中药材NIR频谱区的检测研究[J]. 中国中药杂志,2015,02:287-291.

[10]刘晓娜,张乔,史新元,吴志生*,乔延江*. 基于LIBS技术的树脂类药材快速元素分析及判别方法研究[J]. 中华中医药杂志,2015,05:1610-1614.

[11]刘晓娜,史新元,贾帅芸,赵娜,吴志生*,乔延江*. 基于LIBS技术对4种珍宝藏药快速多元素分析[J]. 中国中药杂志,2015,11:2239-2243.

[12]吴志生,杜敏,潘晓宁,赵娜,史新元*,乔延江*. 硫磺熏蒸的葛根横纵截面快速判别分析[J]. 中国中药杂志,2015,12:2336-2339.

[13]裴艳玲,吴志生*,史新元,潘晓宁,彭严芳,乔延江*. 厚朴酚近红外光谱的2D-COS解析及其在藿香正气口服液模型中应用[J]. 光谱学与光谱分析,2015,08:2119-2123.

[14]吴志生,史新元*,徐冰,戴幸星,乔延江*. 中药质量实时检测:NIR定量模型的评价参数进展[J]. 中国中药杂志,2015,14:2774-2781.

[15]刘姗姗,吴志生,邢玲,于小杰,石航,冯欣,马群*. 基于显微近红外光谱技术的天然牛黄和人工牛黄的鉴别研究[J]. 中华中医药杂志,2014,01:84-87.

[16]彭严芳,史新元,李洋,周璐薇,裴艳玲,华国栋,吴志生*,乔延江*. 基于多变量检测限的模型变量筛选方法研究[J]. 世界科学技术-中医药现代化,2014,05:960-965.

[17]裴艳玲,吴志生*,史新元,周璐薇,乔延江*. 中药关键质量属性快速评价(Ⅱ):NIR光谱解析策略例证[J]. 光谱学与光谱分析,2014,09:2391-2396.

[18]李洋,吴志生*,潘晓宁,史新元,郭明晔,徐冰,乔延江*. 在线近红外光谱在我国中药研究和生产中应用现状与展望[J]. 光谱学与光谱分析,2014,10:2632-2638.

[19]薛忠,徐冰,刘倩,史新元,李建宇,吴志生,乔延江*. 不确定度评估在中药近红外定量分析中的应用[J]. 光谱学与光谱分析,2014,10:2657-2661.

[20]周璐薇*,吴志生,史新元,徐曼菲,张乔,乔延江*. 基于二值化图像结合像元统计法的扑尔敏片剂近红外成像检测参数优化研究[J]. 光谱学与光谱分析,2014,10:2821-2826.

[21]陈昭,吴志生*,史新元,徐冰,赵娜,乔延江*. Bagging偏最小二乘和Boosting偏最小二乘算法的金银花醇沉过程近红外光谱定量模型预测能力研究[J]. 分析化学,2014,11:1679-1686.

[22]乔延江,薛忠,徐冰,戴胜云,吴志生,史新元. 日本药局方“近红外分光光度法”简介[J]. 世界中医药,2013,11:1265-1268.

[23]陈昭,林兆洲,吴志生,乔延江*. 小波变换在NIR定量模型中的应用[J]. 世界中医药,2013,11:1273-1276+1279.

[24]刘晓娜,吴志生,乔延江*. LIBS快速评价产品质量属性的研究进展及在中药的应用前景[J]. 世界中医药,2013,11:1269-1272.

[25]杜敏,吴志生,巩颖,史新元,华国栋,乔延江*. 基于近红外光谱技术的道地山药快速无损分析[J]. 世界中医药,2013,11:1277-1279.

[26]赵娜,吴志生,袁瑞娟,孙杨,詹雪艳,乔延江*. 近红外漫反射光谱法快速测定积雪草总苷中积雪草苷的含量[J]. 世界中医药,2013,11:1280-1282+1286.

[27]隋丞琳,林兆洲,吴志生,徐冰,李洋,史新元,乔延江*. 药渣粒径对中药提取过程在线检测取样系统影响的模拟研究[J]. 分析化学,2013,12:1899-1904.

[28]王运丽,史新元,吴志生,隋丞琳,乔延江*. 利用近红外光谱技术快速检测邻苯二甲酸酯类物质[J]. 中国实验方剂学杂志,2013,05:86-90.

[29]徐冰,史新元*,乔延江*,吴志生,林兆洲. 中药制剂生产工艺设计空间的建立[J]. 中国中药杂志,2013,06:924-929.

[30]彭严芳,史新元,周璐薇,裴艳玲,李洋,吴志生*,乔延江*. 基于四种NIR仪器类型的清开灵注射液中黄芩苷成分的多变量检测限研究[J]. 光谱学与光谱分析,2013,09:2363-2368.

[31]王运丽,史新元,吴志生,程伟,乔延江*. 基于氯化铵溶液的近红外在线定量分析方法的建立[J]. 中国实验方剂学杂志,2012,01:43-47.

[32]吴志生,史新元,隋丞琳,杜敏,彭严芳,乔延江*. 清开灵注射液中间体银黄液中黄芩苷含量近红外测定方法的建立和验证[J]. 中华中医药杂志,2012,04:1021-1024.

[33]隋丞琳,吴志生,林兆洲,徐冰,杜敏,史新元,乔延江*. 样本数据重复性对NIR校正模型的影响[J]. 中国中药杂志,2012,12:1751-1754.

[34]乔延江,杜敏,史新元,吴志生,徐冰. 欧盟制药工业近红外光谱技术应用、申报和变更资料要求指南(草案)[J]. 世界科学技术(中医药现代化),2012,04:1933-1943.

[35]杜敏,吴志生,林兆洲,隋丞琳,史新元,乔延江*. 光程对清开灵注射液中黄芩苷近红外定量模型的影响[J]. 药物分析杂志,2012,10:1796-1800.

[36]吴志生,陶欧,程伟,郁露,史新元,乔延江*. 基于光谱成像技术的乳块消素片活性成分空间分布及均匀性研究[J]. 分析化学,2011,05:628-634.

[37]吴功煌,史新元,吴志生,乔延江*. 后向变量选择偏最小二乘法用于近红外光谱定量校正模型的建立[J]. 数理医药学杂志,2010,03:257-260.

[38].Zhisheng Wu, Wensheng Pang, Meixia Huang, Zhang Jing, Chen Wang, Juan Hu*. Studies the molecular morphology of Ginkgo Biloba Extract. Nat Prod Res Dev Press. 2009, 6, 939-942.

[39]杜晨朝,赵安邦,吴志生,乔延江.近红外光谱结合不同变量筛选方法用于金银花提取过程中绿原酸量的在线监测[J].中草药,2017,48(16):3317-3321.

[40]刘晓娜,郑秋生,车晓青,吴志生,乔延江.基于QbD理念的安宫牛黄丸整体混合终点评价方法研究[J].中国中药杂志,2017,42(06):1083-1088.

[41]杜晨朝,吴志生,赵娜,周正,史新元,乔延江.基于两类误差检测理论金银花提取过程的MEMS-NIR在线分析建模方法研究[J].中国中药杂志,2016,41(19):3563-3568.

 

基本信息

邮箱: wzs@bucm.edu.cn; zhishengfj@126.com

地址: 北京房山区良乡大学城北京中医药大学中药楼C406

研究身份:Researcher ID: I-4566-2013;ORCID: 0000-0002-4004-9728